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Common Side Effects Inhaled DMT produces immediate physiological responses in virtually all users regardless of dose or prior experience: Common DMT vape pen side effects include: Cardiovascular: Rapid heart rate elevation, increased blood pressure, flushing, and chest tightness occurring within the first 60 seconds of inhalation Sensory: Intense auditory and visual hallucinations, time distortion, and tactile alterations that prevent voluntary motor control throughout the peak phase Gastrointestinal: Nausea, vomiting, and abdominal discomfort, particularly with large doses or re-dosing within a single session Psychological Risks and Hallucinogen Persisting Perception Disorder (HPPD) DMT vaporization triggers 5-HT2A serotonin receptor agonism of sufficient intensity to precipitate acute psychological crisis in individuals without any prior psychiatric history
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